The Bosque laboratory is a member of the DC Center for AIDS Research (DC CFAR) within the Department of Microbiology, Immunology, and Tropical Medicine at The George Washington University School of Medicine and Health Sciences in Washington, D.C. The existence of latent reservoirs of HIV-infected cells constitutes the major impediment towards viral eradication. We are currently investigating the mechanisms that control HIV persistence to identify novel mechanisms that can be used towards HIV eradication strategies.
The Bosque lab is seeking to understand the mechanisms that control the entry and exit of HIV into latency. These studies are directed towards the identification of novel mechanisms that can safely reactivate and eliminate (“shock and kill”) or inactivate latent HIV-1 with the purpose of using this knowledge towards HIV-1 eradication strategies.